{"id":52738,"date":"2017-06-29T17:05:42","date_gmt":"2017-06-29T15:05:42","guid":{"rendered":"http:\/\/www.reunion68.se\/?p=52738"},"modified":"2017-06-21T06:47:21","modified_gmt":"2017-06-21T04:47:21","slug":"06-00-19","status":"publish","type":"post","link":"https:\/\/www.reunion68.se\/?p=52738","title":{"rendered":"A Rare Genetic Defect May Lead to a New Cancer Drug"},"content":{"rendered":"
\"\"<\/a>A Rare Genetic Defect May Lead to a New Cancer Drug<\/a><\/strong><\/span><\/h5>\n

Courtesy of israelnn.com<\/strong><\/span><\/p>\n

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The path to understanding what goes wrong in cancer could benefit from a detour through studies of rare childhood diseases. Dr. Ayelet Erez explains that cancer generally involves dozens \u2013 if not hundreds \u2013 of mutations, and sorting out the various functions and malfunctions of each may be nearly impossible.<\/strong><\/p>\n

Rare childhood diseases, in contrast, generally involve mutations to a single gene. Erez, a geneticist and medical doctor who treats families with genetic cancer in addition to heading a research lab in the Weizmann Institute of Science\u2019s Biological Regulation Department, says that children with rare genetic syndromes may serve as a \u201clens\u201d when trying to understand the role of a specific gene in a complex disease such as cancer. She and her team have been focusing their sights on a protein they discovered in this way; promising lab tests indicate that blocking this protein might slow the progression of some cancers.<\/span><\/p>\n

Her findings place this research in the new field of \u201ccancer metabolism,\u201d which seeks to understand how the aberrant, or uncontrolled metabolic processes in cancers might turned against them to stop their growth.<\/span><\/p>\n

She and her team studied cells from children suffering from an extremely rare disease, citrullinemia type II, who are missing the gene for a protein called citrin. Clinically, children with this disease tend to be smaller than average, and to avoid candy. Her research revealed that this protein normally helps keep the body supplied with an amino acid called aspartate which is required to produce DNA and RNA in addition to the breakdown of glucose; so deficiency in this protein causes the cells to divide less.<\/span><\/p>\n

Research into another genetic childhood disease, citrullinemia type I, had already given the team the lens they needed to understand how cancer cells rely on aspartate to divide and migrate. Children born with this disease are missing a gene called ASS1; the lack of ASS1 connects the disease to particularly aggressive, hard-to-treat cancers in which this gene tends to be silenced or mutated. Since this gene also requires aspartate to function, Erez and her team surmised that the silencing had less to do with the gene\u2019s function and more with competition for aspartate and the cancer cells\u2019 craving for ever more of this amino acid to help them divide and spread. Interestingly, the dependence on citrin for aspartate supplementation is seen in cancers both with and without ASS1 expression.<\/span><\/p>\n

Ayelet and her team realized that citrin \u2013 the protein that helps regulate childhood growth \u2013 could present a possible target for anticancer therapies. Blocking this protein would hopefully disrupt the cancer\u2019s overactive metabolic cycle, diminish the cancer cells\u2019 aspartate supply and slow their growth, thus making them less aggressive, less likely to spread and possibly more treatable with other, conventional means. To that end, Erez and her group have been developing a molecule to block citrin, and testing it in the lab. Yeda Research and Development Co., Ltd., the technology transfer arm of the Weizmann Institute of Science, is working with Erez to advance her research to the point that it can be developed for biomedical application.<\/span><\/p>\n

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Dr. Ayelet Erez\u2019s<\/strong> research is supported by the Moross Integrated Cancer Center; the Irving B. Harris Fund; the Adelis Foundation; the Rising Tide Foundation; the Comisaroff Family Trust; and the European Research Council. Dr. Erez is the incumbent of the Leah Omenn Career Development Chair.<\/em><\/span><\/p>\n

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A Rare Genetic Defect May Lead to a New Cancer Drug Courtesy of israelnn.com The path to understanding what goes wrong in cancer could benefit from a detour through studies of rare childhood diseases. Dr. Ayelet Erez explains that cancer generally involves dozens \u2013 if not hundreds \u2013 of mutations, and sorting out the various […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[26,24],"_links":{"self":[{"href":"https:\/\/www.reunion68.se\/index.php?rest_route=\/wp\/v2\/posts\/52738"}],"collection":[{"href":"https:\/\/www.reunion68.se\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.reunion68.se\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.reunion68.se\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.reunion68.se\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=52738"}],"version-history":[{"count":5,"href":"https:\/\/www.reunion68.se\/index.php?rest_route=\/wp\/v2\/posts\/52738\/revisions"}],"predecessor-version":[{"id":52767,"href":"https:\/\/www.reunion68.se\/index.php?rest_route=\/wp\/v2\/posts\/52738\/revisions\/52767"}],"wp:attachment":[{"href":"https:\/\/www.reunion68.se\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=52738"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.reunion68.se\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=52738"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.reunion68.se\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=52738"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}