{"id":65217,"date":"2018-11-30T17:05:05","date_gmt":"2018-11-30T15:05:05","guid":{"rendered":"http:\/\/www.reunion68.se\/?p=65217"},"modified":"2018-11-24T15:48:54","modified_gmt":"2018-11-24T13:48:54","slug":"20-05-37","status":"publish","type":"post","link":"https:\/\/www.reunion68.se\/?p=65217","title":{"rendered":"Israeli scientists develop implanted organs that won\u2019t be rejected"},"content":{"rendered":"
\"Israel21c\"<\/a>Israeli scientists develop implanted organs that won\u2019t be rejected<\/a><\/strong><\/span><\/h5>\n

ISRAEL21c Staff <\/strong><\/span><\/p>\n

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Breakthrough development uses a patient’s own stomach cells, cutting the risk of an immune response to implanted organs.<\/strong><\/p>\n

Regenerative medicine illustration by Valentina Kru via Shutterstock.com<\/em><\/span><\/p>\n

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Israeli researchers report that they have invented the first fully personalized tissue implant, engineered from a patient\u2019s own materials and cells. The new technology makes it possible to engineer any kind of tissue implant, for the spinal cord, to the heart, or brain, from one small fatty tissue biopsy.<\/span><\/p>\n

\u201cWe were able to create a personalized hydrogel from the materials of the biopsy, to differentiate fatty tissue cells into different cell types and to engineer cardiac, spinal cord, cortical and other tissue implants to treat different diseases,\u201d said lead researcher Prof. Tal Dvir of Tel Aviv University\u2019s Center for Nanoscience and Nanotechnology and Sagol Center for Regenerative Biotechnology.<\/span><\/p>\n

\u201cSince both the cells and the material used derive from the patient, the implant does not provoke an immune response, ensuring proper regeneration of the defected organ,\u201d Dvir explained.<\/span><\/p>\n

The research was conducted by Dvir\u2019s postdoctoral researcher, Reuven Edri, and doctoral students Nadav Noor and Idan Gal, in collaboration with Prof. Dan Peer and Prof. Irit Gat Viks of TAU\u2019s Department of Cell Research and Immunology and Prof. Lior Heller of Assaf HaRofeh Medical Center in Israel. It was\u00a0recently published<\/a><\/strong><\/span>\u00a0in the journal Advanced Materials.<\/span><\/p>\n

Avoiding anti-rejection drugs<\/strong><\/p>\n

Currently, in tissue engineering for regenerative medicine, cells are isolated from the patient and cultured in biomaterials to assemble into a functional tissue. These biomaterials can be synthetic or natural, derived from plants or animals.<\/span><\/p>\n

After transplantation, they may induce an immune response that leads to rejection of the implanted tissue. Patients receiving engineered tissues or any other implants are treated with immuno-suppressors, which unfortunately can endanger the health of the patient.<\/span><\/p>\n

The new method solves that problem.<\/strong><\/p>\n

\u201cWith our technology, we can engineer any tissue type, and after transplantation we can efficiently regenerate any diseased or injured organ \u2014 a heart after a heart attack, a brain after trauma or with Parkinson\u2019s disease, a spinal cord after injury,\u201d said Dvir.<\/span><\/p>\n

\u201cIn addition, we can engineer adipogenic [fatty tissue] implants for reconstructive surgeries or cosmetics. These implants will not be rejected by the body.\u201d<\/span><\/p>\n

The researchers extracted a small biopsy of fatty tissue from patients, then separated its cellular and a-cellular materials. While the cells were reprogrammed to become induced pluripotent stem cells \u2014 able to make cells from all three basic body layers, so they can potentially produce any cell or tissue the body needs to repair itself \u2014 the extracellular material was processed to become a personalized hydrogel.<\/span><\/p>\n

After combining the resulting stem cells and the hydrogel, the scientists successfully engineered the personalized tissue samples and tested the patients\u2019 immune responses to them.<\/span><\/p>\n

The researchers are currently engaged in regenerating an injured spinal cord and an infarcted heart with spinal-cord and cardiac implants. They have also begun to investigate the potential of human dopaminergic implants to treat Parkinson\u2019s disease in animal models.<\/span><\/p>\n

The researchers plan to regenerate other organs, including intestines and eyes, using the patients\u2019 own materials and cells.<\/span><\/p>\n

\u201cWe believe that the technology of engineering fully personalized tissue implants of any type will allow us to regenerate any organ with a minimal risk of immune response,\u201d Dvir said.<\/span><\/p>\n

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Israeli scientists develop implanted organs that won\u2019t be rejected ISRAEL21c Staff Breakthrough development uses a patient’s own stomach cells, cutting the risk of an immune response to implanted organs. Regenerative medicine illustration by Valentina Kru via Shutterstock.com   Israeli researchers report that they have invented the first fully personalized tissue implant, engineered from a patient\u2019s […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[26,24],"_links":{"self":[{"href":"https:\/\/www.reunion68.se\/index.php?rest_route=\/wp\/v2\/posts\/65217"}],"collection":[{"href":"https:\/\/www.reunion68.se\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.reunion68.se\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.reunion68.se\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.reunion68.se\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=65217"}],"version-history":[{"count":3,"href":"https:\/\/www.reunion68.se\/index.php?rest_route=\/wp\/v2\/posts\/65217\/revisions"}],"predecessor-version":[{"id":65226,"href":"https:\/\/www.reunion68.se\/index.php?rest_route=\/wp\/v2\/posts\/65217\/revisions\/65226"}],"wp:attachment":[{"href":"https:\/\/www.reunion68.se\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=65217"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.reunion68.se\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=65217"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.reunion68.se\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=65217"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}